According to "Shaanxi News", at Xijing Hospital in Xi'an, a polygene-edited pig skin transplant was used to treat a patient with severe burns.xenotransplantation surgeryDeclared a success, this is also the first time our country has achieved this result. According to reports, the treatment of extremely severe burns has always been a medical problem in the world. The use of allogeneic skin to temporarily cover burn wounds is the key to successful treatment, but its source is severely limited.
Many experts around the world have also tried to cover it with ordinary pig skin, but it is very easy to cause acute rejection and it is difficult to achieve the therapeutic effect.Using gene editing technology to reduce the rejection of pig skin by the human immune system and improve the success rate of treatment for extremely severe burnsIt is a hot research direction at the moment, but it is also very difficult.
Last year, Xijing Hospital carried out the world's first multi-gene-edited pig-monkey multi-organ and multi-tissue simultaneous transplantation. During this period, pig-monkey skin transplantation was simultaneously performed, and a gene-edited pig skin deep cryopreservation and recovery technology system was established.
In June this year, a patient with flame burns covering 90% of his body and 50% of III-degree burns was sent to the hospital. After extensive research and judgment by experts, and with the consent of his family and multiple reviews, the treatment team formulated a multi-gene-edited pig skin transplant surgery.
After the operation, the transplanted pig skin survived well without obvious rejection.The burn wounds have all healed so far, the operation was a major success, which further proved that gene-edited pig skin is expected to replace allogeneic skin and become a new option for clinical treatment of patients with severe burns.