[Ministry of Science and Technology: It is necessary to reveal the underlying scientific issues and technical principles "from 1 to 0" around strategic areas related to national security and major interests] On September 29, Yin Hejun, Minister of the Ministry of Science and Technology, said at a press conference of the State Council Information Office that during the "15th Five-Year Plan" period, original innovation capabilities will be comprehensively improved and the foundation of a scientific and technological power will be built. To strengthen the strategic, forward-looking and systematic layout of basic research, we must not only face the world's technological frontiers, strengthen original innovation "from 0 to 1", and actively explore "no man's land"; we must also focus on strategic areas related to national security and major interests, and reveal the underlying scientific issues and technical principles of "from 1 to 0". It is necessary to accelerate the advancement of artificial intelligence-empowered scientific research and lead the transformation of scientific research paradigms. Strengthen the construction of high-quality discipline systems, focus on cultivating emerging disciplines and developing interdisciplinary disciplines.