According to news on September 27, Yin Ye, CEO of BGI Group, recently stated at the Phoenix Bay Area Financial Forum 2023 that the United States had just completed the second successful human-to-human transplantation generated in a pig the day before yesterday.Xenogeneic organ transplantation can use gene editing to regenerate new things for us.
Yin Ye also said that in 2013, more discussions were about 3D printing, and cell printing was gradually used to print cells, tissues, and organs.Today, it is possible to use gene editing technology to directly produce human hearts or human kidneys in pigs.
It is reported that the University of Maryland Medical Center in the United States recently completed the world's second operation to transplant a genetically modified pig heart to a patient.
The patient is still in the observation period and is recovering well. He can sit up in a chair and even joke two days after the operation.
Like the first time, the pig hearts used by the surgical team this time were provided by Revivecor, a subsidiary of United Therapeutics, and also involved 10 specific gene edits.
Among them, three genes were "knocked out" or inactivated to reduce the risk of triggering a severe reaction from the human immune system; one gene was modified to prevent excessive proliferation of pig heart tissue; and six human genes were added to improve the acceptance of the human immune system and promote the body's acceptance of xenogeneic organs.
In addition, scientists have successfully cultivated human mid-stage kidneys in pigs., the proportion of human cells in the kidney can reach up to 70%, and the proportion of mesonephric tubules formed by human cells can reach up to 58%.
Human donor cells have differentiated into functional cells expressing these genes, indicating that human donor cells in kidney-deficient pig fetuses will be able to support the generation of humanized kidneys as the embryo develops.
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