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[The complex brains of cephalopods are related to the three-dimensional folding of DNA] On October 12, a study published by the University of Vienna in Austria in the latest issue of "Nature Communications" found that cephalopods can evolve complex nervous systems. The reason is not only genetic mutations, but also the three-dimensional folding of DNA in cells that may actively affect evolution. Large-scale genome recombination hundreds of millions of years ago turned DNA fragments that were originally far apart into "neighbors" and gradually formed a huge regulatory network, providing conditions for the emergence of complex nervous systems. The research team reconstructed the three-dimensional organization of the animal's genome and combined it with gene activity data to interpret it.
#DNA#genome#Gene#cell#animal#Global market intelligence10-12 07:04
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[For the first time in the world, a Chinese team constructed a three-dimensional spatio-temporal cell map of the entire rice life cycle] On October 7, the reporter learned from the Yazhou Bay National Laboratory that the latest rice research results, completed by the collaboration of multiple scientific research institutions in China, were published online in the international academic journal Cell on the evening of the 6th. The content is that a Chinese research team has constructed for the first time in the world a three-dimensional spatio-temporal cell map covering the entire process of rice from seed germination to flowering and fruiting. It integrates genome sequencing, single-cell sequencing and spatial transcriptome sequencing, providing new research resources for understanding rice growth and development and exploring grain quality improvement. (CCTV News)
#genome#Gene#cell#research#agricultural planting10-07 09:28
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[Chinese researchers decipher the "bacterial code" of migratory locusts gathering to lay eggs] On October 2, we learned from the Institute of Agricultural Genomics, Chinese Academy of Agricultural Sciences, that recently, the Agricultural Pest Genomics Innovation Team of the Institute of Agricultural Genomics, Chinese Academy of Agricultural Sciences, in conjunction with many scientific research units at home and abroad, revealed the molecular mechanism by which migratory locusts gather and lay eggs with the help of maternally transmitted symbiotic bacteria. Relevant research results were published in Cell.
#genome#molecular#Gene#cell#research#bacteria10-02 11:55
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[Functional map of genes regulating changes in human bones released] On September 28, institutions such as the Institute of Advanced Human Biology at Kyoto University in Japan released the first functional map of the "human bone gene switch" in the latest issue of "Nature". This study combines whole-genome alignment, massively parallel reporter analysis of chondrocytes, and "human-great ape hybrid cells" to show that cartilage maintenance molecules glycosaminoglycans (GAGs) have been significantly reduced during human evolution, providing evidence for understanding bone formation and why humans are more susceptible to osteoarthritis.
#biology#genome#molecular#Gene#cell#Global market intelligence09-28 07:15
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["Prime assembly" can accurately stitch long DNA fragments] On September 21, a research team from Boston Children's Hospital in the United States published a new genome editing method called "prime assembly" in the latest issue of "Nature" magazine. This technology can precisely "stitch" long DNA fragments to precise programmable sites in the genome of living cells, and repair multiple mutations simultaneously in one operation. This advance could lead to the development of universal gene therapies suitable for most patients.
#gene therapy#DNA#genome#programming#Gene#cell#Global market intelligence09-21 06:37
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[Inner Mongolia: The output value of the biomanufacturing industry will reach more than 100 billion yuan by 2030] On September 11, the General Office of the People's Government of the Inner Mongolia Autonomous Region recently issued the "Action Plan for Accelerating the High-quality Development of the Biomanufacturing Industry in the Inner Mongolia Autonomous Region." It is proposed that by 2030, the scale of the bio-manufacturing industry will continue to expand, the entire industry chain will be gradually built, and it will become an important engine for the development of new productivity in the autonomous region. The output value will reach more than 100 billion yuan, and the number of bio-manufacturing enterprises in the region will be strived to reach more than 500, among which, enterprises above designated size will reach To more than 200 companies, Hutong Chiba Bio-manufacturing Industry Cluster will be supported to create a national-level advanced manufacturing cluster; scientific and technological innovation capabilities will be significantly enhanced, and an important national bio-manufacturing technology innovation node will be basically established. The world's largest lactic acid bacteria and other microbial germplasm resources and genome database will be built to consolidate Traditional advantages include maintaining the international leading level in key indicators such as amino acid fermentation efficiency and veterinary vaccine research and development; industrial upgrading is accelerated, industrialization of key materials such as polylactic acid and bio-based nylon is realized, and the application proportion of non-grain raw materials is gradually increased; market entities and brand cultivation systems are accelerated to build 2- 3 local leading enterprises with a revenue of 5 billion yuan, more than 1 national-level specialized, special and new "little giant" enterprises, more than 5 autonomous region-level specialized, special and new small and medium-sized enterprises, and 2-3 brand products with strong competitiveness in the domestic market, introduce more than 2 well-known domestic and foreign companies to set up production bases.
#database#genome#microorganism#Gene#vaccine#biopharmaceutical09-11 17:16
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[AI Model Interprets the "Grammar" of Three Billion Bases] On September 11, a team from the University of California, Berkeley, created the genome language model GPN-Star, which can interpret the "grammar" of three billion bases and identify human genetic variations faster and more accurately. The model uses whole-genome alignment data to learn from evolution and is trained at a much lower computational cost than larger models. The team simultaneously released genome-wide predictive annotations for biologists to screen pathogenic variants and regulatory elements for priority experiments. A related paper was published in the journal Nature on the 9th.
#biology#genome#Gene#Global market intelligence09-11 06:52
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[The most comprehensive map of the molecular effects of human gene mutations released] September 10th, according to the British "Nature" website, DeepThink, a subsidiary of Google, released the human genome map - Alpha Genome Atlas - on the 8th. The map covers the potential effects that may be caused by approximately 9 billion single nucleotide variations (changes in a single DNA letter) in the human genome, and is the most comprehensive catalog of the molecular effects of genetic mutations to date. It not only helps screen for disease-causing mutations, but also discovers key mutations that have been overlooked in rare disease research, opening up new avenues for precision medicine.
#DNA#genome#Rare disease#Google#molecular#Gene#Global market intelligence09-10 07:02
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[China takes the lead in formulating the world's first international standard for pathogenic gene databases] September 2nd, reporters learned from the National Standards Committee today that the world's first international standard for pathogenic gene databases, led by China, has been formally established recently. It will establish a unified "standard" for the construction of global pathogenic microorganism genome databases. The pathogenic microorganism genome reference database is equivalent to a genetic reference dictionary. By comparing the genetic information in the patient sample with the entries in this dictionary, you can identify which virus or bacteria it is, and doctors can treat it accordingly. This time, the international standard led by China is to compile this "pathogen gene dictionary" for the world. After the standard is implemented, the unified database can accurately identify difficult infection cases and greatly reduce the probability of misdiagnosis and missed diagnosis. At the same time, it can help countries quickly identify the source of the epidemic, track the transmission path, and provide standardized and reliable technical support for epidemic prevention and control. (CCTV Finance)
#database#genome#microorganism#Gene#bacteria#Virus#Cutting edge information on science and technology09-02 15:33
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[Pathogen metagenomic detection reagents based on second-generation sequencing technology approved for marketing] On August 31, the State Food and Drug Administration disclosed that the State Food and Drug Administration recently approved the registration application for two pathogenic metagenomic detection reagents based on second-generation sequencing technology, namely the respiratory pathogen nucleic acid detection kit (combined probe-anchored polymerization sequencing method) of Guangzhou Weiyuan Medical Equipment Co., Ltd. and the bloodstream infection pathogen nucleic acid detection kit (reversible end termination sequencing method) of Tianjin Golden Key Medical Technology Co., Ltd.
#genome#medicine#Gene08-31 17:34
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[The world's first pathogen metagenomic detection reagents approved by China] August 31st, the State Food and Drug Administration today (31st) recently approved the listing of two "pathogen metagenomic detection reagents", including a "global new" respiratory acute and critical illness pathogen detection reagent and a "China's new" bloodstream infection pathogen detection reagent.
#genome#Gene#influenza08-31 15:11
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[Extreme high temperatures may be associated with 33 health problems] August 31, a new study from Northwestern University in the United States shows that extreme high temperatures are related to a wider range of health problems such as skin diseases and multiple sclerosis, and may even induce traffic accidents. The relevant paper was published in the new issue of "Science Advances" magazine. Heat-related illnesses have been difficult to track because medical records often document only the conditions being treated and often ignore the underlying cause. Inspired by genomics research methods, the research team used a new framework to comb through 1,803 diagnoses from nearly 1 million emergency and urgent care visit records in Chicago from May 2011 to September 2023, and finally identified 33 health problems related to extreme heat exposure, including rashes and swelling, acute renal failure, multiple sclerosis, mental and behavioral disorders, insect bites, as well as traffic accidents, violent attacks, and gun-related injuries.
#genome#Gene#Global market intelligence08-31 06:56